The role of Parf, a novel partner of ARF, in pancreatic ductal adenocarcinoma and in ARF signaling
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چکیده
Approved: _______________________________________________________ Thesis Supervisor _______________________________________________________ Title and Department _______________________________________________________ Date THE ROLE OF PARF, A NOVEL PARTNER OF ARF, IN PANCREATIC DUCTAL ADENOCARCINOMA AND IN ARF SIGNALING by Viviane Palhares Muniz A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Molecular and Cellular Biology in the Graduate College of The University of Iowa
منابع مشابه
Correction: Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-κB Signaling Pathways
BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in the United States, suggesting that novel strategies for the prevention and treatment of PDAC are urgently needed. K-ras mutations are observed in >90% of pancreatic cancer, suggesting its role in the initiation and early developmental stages of PDAC. In order to gain mechanistic insight as ...
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تاریخ انتشار 2016